More than a center for excellence, the Andrews Research & Education Foundation (AREF) brings together the highest level of sports medicine researchers and medical professionals. This collaboration delivers opportunities on many levels. We partner with industry leaders to research cutting edge solutions that impact the future of sports medicine. In collaboration with the Andrews Institute, a world class epicenter for orthopaedics and sports medicine in Northwest Florida, and under the leadership of nationally and internationally renowned orthopedic surgeon James Andrews, MD, AREF has further secured Northwest Florida as a cradle for musculoskeletal treatments and research.

The Andrews Institute is comprised of several divisions including: Multi-specialty Ambulatory Surgery Center, Outpatient Rehabilitation, Diagnostic Imaging Center, Athletic Performance Center, Andrews Research & Education Foundation, and a multispecialty office park for physicians. The Andrews Institute is located on property contiguous to the Gulf Breeze Hospital in Gulf Breeze, Florida. The Andrews Institute, which has orthopaedic and sports medicine specialty physicians along with a Sports Medicine Fellowship, has attracted national and international attention to the area for its superior medical care in orthopaedics and research.

Physician specialties within Andrews Institute include Orthopaedic/Sports Medicine, Pain management, Neurosurgery, Neuroscience, Ophthalmology, Plastic Surgery, Orthodontics, Podiatry and General and Vascular Surgery. We deliver our evidence based content on many levels including; webinars, seminars, conferences, and on-site training. We welcome opportunities to partner with industry leaders to bring new and groundbreaking solutions to sports medicine.


For More Information: 850-916-8591

“Working with the research team at the Andrews Research & Education Foundation has been a true pleasure. Their professional while friendly approach makes communicating with the team enjoyable and productive. They understand and respect the meaningful details required for ensuring regulatory and protocol compliance which results in confidence that our research project is being managed properly. Exactech truly appreciates the work they do, and look forward to engaging in future projects.”
– Matthew Peterson, PhD, Senior Clinical Project Manager, Exactech, Inc.

Investigator – James Andrews, MD

Study Sponsor – Pacira Pharmaceuticals

Study Title – The Effect of EXPAREL® on Postsurgical Pain, and the Use of Narcotics

Study Description -The purpose of this study is to determine if the product EXPAREL®, can be used as a safe alternative in shoulder surgery to pain pumps, while limiting narcotic use and providing appropriate postoperative pain control.

*This study is no longer enrolling patients

Investigator – Christopher O’Grady, MD

Study Sponsor – Rotation Medical

Study Title – Rotation Medical Bioinductive Implant Database (REBUILD) Registry

Study Description -The purpose of this registry is to evaluate how shoulder function and quality of life change over time after shoulder surgery using the Rotation Medial Bioinductive Implant.

Investigator – Adam Anz, MD

Study Sponsor – KLSMC

Study Title – A multicenter, randomized, open-label, standard treatment-controlled parallel group phase 2 study to evaluate efficacy and safety of intra-articular injections of autologous peripheral blood stem cells and hyaluronic acid adjuvant therapy following subchondral drilling surgery for the treatment of articular cartilage injury in the knee with an optional open-label extension for the standard treatment-controlled group

Study Description – To evaluate the effect of intra-articular injections of peripheral blood stem cells together with hyaluronic acid after subchondral drilling surgery and postoperative physiotherapy on functional outcomes and pain of the knee joint relative to standard treatment.

Investigator – Brett Kindle, MD, Adam Anz, MD, Joshua Hackel, MD, Michael Milligan, MD, & Roger Ostrander, MD

Study Sponsor – Zimmer Biomet

Study Title – A Multicenter, Double-Blind, Randomized, Saline-Controlled Study of a Single, Intra-Articular Injection of Autologous Protein Solution in Patients with Knee Osteoarthritis

Study Description – A double-blind, multicenter, randomized, saline-controlled trial (RCT) that will evaluate the efficacy of a single dose of Autologous Protein Solution (APS) in patients with symptomatic osteoarthritis (OA) of the knee who have not been able to get satisfactory pain relief with prior treatment.

*This study is no longer enrolling patients

Investigator – Joshua Hackel, MD

Study Sponsor – EmCyte

Study Title – Efficacy of bone marrow aspirate concentrate compared with platelet rich plasma for the treatment of symptomatic knee osteoarthritis: A randomized, controlled clinical trial.

Study Description – This study is to compare the effectiveness of bone marrow aspirate concentrate (BMA) to platelet rich plasma (PRP) injections for the treatment of knee osteoarthritis.

*This study is no longer enrolling patients

Investigator – Charles Roth, MD

Study Sponsor – FIDIA

Study TitleA post-market, single blind, multicenter, randomized, controlled trial of HYMOVIS® intra-articular injections in active subjects with knee osteoarthritis

Study Description – A study of HYMOVIS® hyaluronan based viscoelastic hydrogel combined with a physical exercise program to decrease pain associated with osteoarthritis of the knee.

Investigator – Joshua Hackel, MD

Study Sponsor – AMSSM

Study Title – Practical Indications for Sonography in Musculoskeletal Medicine- Knee Joint Injections (PRISMM-Knee).

Study Description – To determine the most accurate and clinically effective way to inject the knee joint by comparing the two most commonly performed intra-articular injection techniques with or without ultrasound guidance.

*This study is no longer enrolling patients

Investigator – Christopher O’Grady, MD

Study Sponsor – Flexion Therapeutics, Inc.

Study Title – An Open-label Study to Assess the Safety of Repeat Administration of FX006 to Patients With Osteoarthritis of the Knee

Study Description – This study is an open-label, repeat administration design of 40 mg FX006. The study will be conducted in male and female patients ≥ 40 years of age with symptomatic OA of the knee.

*This study is no longer enrolling patients

Investigator – Michael Hartsfield, MD

Study Sponsor – Exactech, Inc.

Study Title – A Post-Market Domestic (US) and International Data Collection to Assess the Optetrak® Knee System

Study Description – The purpose of this study is to collect prospective and retrospective clinical outcomes data to further affirm the safety and effectiveness of the Optetrak® Knee System product lines.

*This study is no longer enrolling patients

Investigator – Adam Anz, MD, Steve Jordan, MD, & Roger Ostrander, MD

Study Sponsor – Arthrex

Study Title – Pilot Study: Augmentation of ACL Reconstruction with Bone Marrow Stem Cells and Amnion Collagen Matrix Wrap

Study Description – An initial pilot study looking at the outcomes of wrapping an ACL graft with a collagen matrix and injecting bone marrow aspirate into the wrap to augment ACL surgery for accelerating and improving graft maturation and the ligamentization process.