Andrews Institute Teams Up with Emory, Duke Universities on Stem Cell Research

While it might sound great to have a brand new knee if you suffer from severe arthritis, knee replacement surgery is pretty severe. Soon, you may have more options available than just surgery. There is a new slate of medical options being discovered at the Andrews Institute to treat arthritis through minimally invasive procedures.

Along with Emory University, Duke University, and Sanford Health, the Andrews Research and Education Foundation (AREF) is conducting a research study comparing three different kinds of stem cells with the current gold standard treatment for arthritis - corticosteroid injections. 

Many patients with osteoarthritis in the knee eventually require surgery as their condition worsens. This study is looking at ways to prevent the need for knee replacement surgery through the use of stem cells to help the knee cartilage repair itself. 

As part of the study, participants receive injections of stem cells from their own belly fat (adipose tissue), bone marrow, or stem cells from a tissue donor. The control group receives the traditional steroid shot. Study participants are then monitored at different intervals over the next few years by MRI screenings to measure what, if any, improvement is taking place in the knee joint.

Dr. Josh Hackel, who is the principal investigator for this study at Andrews, became interested in sports medicine after having multiple knee surgeries while still in high school. 

I did my ninth-grade science project about my own knee surgery, with a poster presentation that documented the recovery. I still have it framed in my office,” said Hackel. 

Thirty years later his fascination with optimal knee function hasn’t abated. While his surgeries were a positive experience, Dr. Hackel now focuses on non-surgical treatments, which allows him to be a “one-stop shop” of quick diagnosis, minimally invasive treatments, and a return to health. Patients don’t have to wait to make a separate appointment to get an MRI for treatment. Hackel can use ultrasound technology, often on the first visit, to diagnose the patient’s condition and begin planning and executing a course of treatment.

Dr. Hackel explains that, “the Andrews Institute was built based on the principle that we would not only focus on patient and physician education, but also work to investigate and prove better, safer ways to treat musculoskeletal injuries. If we can do that, we can return the patient back to their normal activities faster, with less pain and less risk of reinjury or infection.”

Since roughly one in four Americans suffer from arthritis, having an institution on the forefront of orthopedic and regenerative medicine, pain relief, and regeneration is a boon for residents in the Gulf Coast area and beyond.

Dr. Hackel sums up the philosophy of the Andrews Institute by saying, “we are trying to take everyday problems and figure out better, safer, and less painful ways to treat them. That's pretty awesome for patients here on the Gulf Coast, or in the southeastern United States.  

They don't have to travel internationally, or to New York or the West Coast to get these cutting-edge treatments. We’re doing those same treatments, actually researching them, testing them, and improving them - right here at the Andrews Institute.”

Excellence and Innovation Define Andrews Research & Education Foundation

Excellence and Innovation Define Andrews Research & Education Foundation

World-renowned orthopedic surgeon Dr. James R. Andrews is often highlighted on major sports networks, credited for saving the careers of professional athletes, and cited in national and international medical journals. But his most important accomplishment may be the constant drive for innovation and improvement he inspires in his colleagues.

Pensacola-based Andrews Research & Education Foundation is one of Andrews’s accomplishments that is quietly changing the orthopedic and sports medicine industry. The research arm of the Andrews Institute, this foundation is undertaking ground-breaking research normally reserved for major biotech companies or large universities.

One of the local doctors engaged in the research at AREF is Dr. Adam Anz. As a highly sought-after orthopedic surgeon, Anz works full time performing surgery and helping his patients as his “day job.” But he is also leading several research projects looking to improve how those patients can recover and sustain their health over the long-run.


One such study is sponsored by the State of Florida to look at ways to improve patient outcomes after ACL reconstruction surgery of the knee. According to Anz, 85% of patients develop some type of arthritis, known as Post-Traumatic Osteoarthritis (PTOA) within 15 years of ACL surgery. Traditional thinking accepted this long term cost as the price for serious damage.

Leading With Innovation

At the Andrews Research & Education Foundation, traditional thinking isn’t enough. Anz says orthopedic surgeons are great at repairing the structure of the knee, or as he calls it, the carpentry. But what the industry hasn’t kept up with is the actual biology of how the body responds over the long-run to the injury itself and the trauma of the surgery.

Anz puts it this way, “When you have that injury event, your immune system ramps up with an initial inflammatory response, and that response completely affects that part of your body afterwards.”

One way to minimize those immune system impacts might be platelet-rich plasma, or PRP, says Anz. While in medical school, Anz learned about - and worked on - international studies suggesting that the use of the body’s cells (known as biologics) could help post-surgical outcomes in both the long and short term. He was determined to bring these ideas back to the U.S. and prove in trials sanctioned by the FDA and medical Institutional Review Boards (IRB) that using the body’s own cells, in this case platelet rich plasma (PRP), can help patients heal better.

“How can we manage the biology as much as the carpentry of the situation? How can we utilize some of these tools that are readily available in our own bodies? Platelet rich plasma is basically me taking your blood, minimally manipulating it, and then using it to affect your immune system, which is your body's reaction and maintenance system. So we can use these biologics, whether it be PRP or cells to manipulate your immune system, to help set the table for our stabilization procedures.”

The study currently underway at AREF uses state-of-the-art equipment often found only at major research institutions. These include the enzyme-linked immunosorbent assay (ELISA) testing, as well as flow cytometry to track the impact of PRP before, during, and after surgery to see if those arthritis-producing inflammatory biomarkers are present. If this stage of research shows clinically significant results, then longer term studies will begin.

The Path to Pensacola

Following medical school, Anz wanted to work for an institution that fit his desire to help patients, but that would also support his drive to find the next advancements in orthopedic medicine. It just so happened that Anz found an orthopedic practice that was just as interested in advancing orthopedic research as he was. That practice was with legendary orthopedic surgeon, Dr. Jim Andrews.

“After medical school, I ran into Dr. Andrews and he said, ‘Hey, we're really excited about our facility down in Pensacola, Florida and we're trying to do research there. We know that the first great advancement in sports medicine was the arthroscope, the camera that helps us look inside the joint, and we think that stem cells and biologics is going to be the next. Why don't you come down here and help us do some research in that space?’”

As Anz says, “sometimes you don’t find your path, your path finds you.”

This state-funded investigation, along with other research trials happening at the Andrews Research and Education Foundation, are driving a real change in the way orthopedic surgeons approach their work. But what really makes AREF truly innovative is the environment of collaboration, generosity, and sharing from the lab to the clinic to the patient and back again. A supportive community is important too, and local patients participate in finding breakthroughs of clinical significance. And until Dr. Anz knows your ACL isn’t going to just be better for a year or two, but for twenty years he’s likely to stay pretty busy.

Andrews Research & Education Foundation Part of $13M Clinical Trial for Osteoarthritis

Andrews Research & Education Foundation Part of $13M Clinical Trial for Osteoarthritis

PENSACOLA, Fla. (Sept 23, 2019) -- Andrews Research & Education Foundation (AREF) in Pensacola has partnered with four other leading medical research organizations in a $13 million clinical trial studying the ability of stem cells to treat osteoarthritis in the knee.

Along with Emory Orthopaedics & Spine Center, Duke University, and Sanford Health, AREF will be testing various types of stem cells that will be used to stimulate cartilage growth in the knee joint. The stem cells are administered to the knee through an ultrasound-guided injection, to ensure the stem cells are accurately placed within the joint. Georgia Institute of Technology will be processing the information gathered at each of the four sites.

“We are really proud to be a part of this multi-center trial,” said Ashton Hayward, AREF President. “This kind of research can potentially change the lives of so many people and extend their quality of life in significant ways. It’s a testament to Dr. Andrews and the physicians here at the Andrews Institute to participate in this study with some of the biggest names in medical research.”

These and other less-invasive techniques, often administered in conjunction with ultrasound, are gaining attention as an alternative to traditional surgery, according to Dr. Josh Hackel, who is the primary investigator for the study at AREF. Hackel hopes this research will validate what he and other physicians have been seeing with their own patients - that stem cells can be a viable option for some patients to avoid having full knee replacement surgery.

Each location in the four-site study will have about 120 subjects for the trial and will be testing stems cells from various sources, including the patient’s fat cells, bone marrow-derived stem cells, and umbilical cord tissue cells. They will monitor how each type of cell interacts with knee tissue and measure cartilage regeneration inside the patient’s knee joint. Dr. Hackel has already started treating his first patients in the study, which will last one year.

This clinical trial is being funded entirely by a grant from Bernie Marcus, founder of the Marcus Foundation and co-founder of Home Depot. Osteoarthritis is an issue that is close to the philanthropist's heart because his mother was left disabled by the illness at a young age.

For more information regarding this study, please contact at 850-916-8591.

Hayward Named Andrews Research & Education Foundation President

GULF BREEZE, Fla. (December 11, 2018)– Ashton J. Hayward, III begins serving as president of the Andrews Research & Education Foundation (AREF) effective January 7, 2019. The leadership of AREF selected the former Pensacola mayor to direct the AREF’s efforts to fulfill the mission of being an international leader in bringing new and groundbreaking solutions to sports medicine through research and education.

“Hayward’s visionary leadership and result-oriented mindset will help AREF continue to advance the prevention, treatment and rehabilitation of athletic injuries and enhance human performance and quality of life for people of all ages,” said James Andrews, M.D., founding partner and president of the AREF Board.

Hayward joins AREF from the City of Pensacola where he served as mayor for the past eight years.

“I am honored, humbled and excited to take on this role with the Andrews Research & Education Foundation,” said Hayward. “I deeply believe in the Foundation’s mission to help improve the quality of life for people and professionals all over the country. I look forward to ensuring that AREF is the definitive destination for advancements in sports medicine.”

In addition to leading edge research and evidence-based education, AREF supports doctors and scientists through fellowships, scholarships and grants. The Foundation also facilitates the Eagle Fund, an important program providing world-class care to hundreds of America’s special operations warriors who have been injured.

As mayor, Hayward managed a city staff of nearly 800 team members and a budget of more than $200 million. Hayward’s guidance was integral in economic development initiatives that have created a culture where businesses can grow and thrive in Pensacola.

His advocacy efforts with community and state partners resulted in streamlined operations, reduced crime and improved city services. Prior to serving as mayor, Hayward worked in New York City for AT&T Corporation and the Financial Times.

Andrews Research & Education Foundation Offers Online Continuing Education for Athletic Trainers

November 13, 2018

Gulf Breeze, FL – The Andrews Research & Education Foundation (AREF) is continuing to expanding their education platform to include online courses for continuing education units (CEUs). The course materials will consist of lectures, presentations, and video content that will provide subscribers with full access to the accumulative knowledge of our world renowned physicians and orthopaedic sports medicine healthcare providers. Combining invaluable information with an online education program, AREF will now be able to offer medical personnel a convenient alternative to gain access to higher learning education.

“We are excited to be able to provide the 2018 Injuries in Football Conference course online for athletic trainers,” stated Leandra Price, AREF Education Manager. “This exposure will provide athletic trainers a chance to learn about a variety of injuries and hot topics in football from the best providers that sports medicine has to offer.”

To learn more about our live and online continuing education visit our website

Dr. Brandon Winchester Receives Award for Lead Investigator in a Cutting Edge Research Trial

October 2, 2018

Gulf Breeze, FL – Brandon Winchester, MD is a renowned anesthesiologist known for his expertise in the field of ultrasound guided nerve blocks for orthopedic surgery. As an investigator for the Andrews Research & Education Foundation (AREF), Dr. Winchester was approached by Halyard Health to lead an investigation that would provide real time ultrasound imaging video capture for the development of a regional localization data system. As a result of his proficiency and dedication to research, it was announced by Halyard Health that Dr. Winchester would be recognized for his achievement of being one of the top enrolling investigators for this multicenter research trial.

"When participating in research with the Andrews Research & Education Foundation, anesthesiologists like myself have the unique opportunity to provide safe and efficient clinical care to patients every day while also participating in local and national multi-center studies aimed to advance our specialty and improve international patient care. Balancing advanced clinical practice with cutting edge research is something traditionally reserved for tertiary care academic centers, and is one of the things that makes the Andrews Foundation such a special place to work,” said Dr. Winchester.

Dr. Winchester has collaborated with AREF on a variety of research studies involving the use of ultrasound guided nerve blocks to further develop better outcomes for patients undergoing orthopedic surgery. This new research will allow Halyard Health to develop a database of videos capturing the most commonly used ultrasound guided nerve blocks. The end goal of this exciting study is to have the capabilities to share knowledge from nerve block experts such as Dr. Winchester on a national scale with other practicing anesthesiologist, thus furthering education from research and quality of life for patients.

According to Dr. James R. Andrews, “The thing that sets us apart, and the thing that I emphasize when the foundation was created, is that we need to be involved in education and research and indeed we are doing that at the Andrews Research and Education Foundation.”